General description
Lithium chloride (LiCl) is a lithium salt. It is used as a source of chloride nucleophile as well as a source of chloride ligand in chemical synthesis. LiCl is also used as a desiccant in drying air streams.
Application
Lithium chloride can be used as:
- A source of chloride anion for the conversion of alcohols to alkyl chloride under Mitsunobu conditions.
- An additive in the palladium-catalyzed coupling and carbonylative coupling reactions of organostannanes and vinyl triflates.
- A reagent for the cleavage of protecting groups under mild conditions. It readily converts acetals and ketals to the corresponding carbonyl compounds.
- A reagent in the dehydrohalogenation of α-halocarbonyl compounds to α,β-unsaturated carbonyls compound in the presence of DMF.
LiCl is also used with other reagents:
- LiCl:DIPEA (1:1 molar ratio) is used in Horner–Wadsworth–Emmons alkenation reaction.
- LiCl:Hexamethylphosphoric triamide is used in decarboxylative alkylation and chloride displacement reactions.
- LiCl is used as an additive in solid-phase peptide synthesis because it increases resin swelling and improves the efficiencies of complex coupling steps.
Features and Benefits
- Easy to handle
- Weak Lewis acid
- Highly soluble in water
Other Notes
Go to Redi-Dri™ Product Listing 746460
Legal Information
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC
- UPC:
- 51334601
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 310468-500G
