LMP744 hydrochloride (C09-1142-659)

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activityIn VitroThe GI 50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM. LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G 2 phases of the cell cycle. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity AssayCell Line: P388 and P388 Top1-deficient murine leukemia cells. Concentration: 0.1-100 μM Incubation Time: 3 days Result: Induced dose-dependent accumulation of cells in the S and G 2 phases of the cell cycle.In VivoLMP744 (MJ-III-65) (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts . Dosage: 10, 25, or 50 mg/kg/week, 4 weeks Administration: I.V. push via tail vein Result: Moderately actived against human A253 and FaDu tumor xenografts without significant toxicity.Form:SolidIC50& Target:Top1. Specification: 0.99 Molecular Formula: C24H25ClN2O7 Molecular Weight: 488.92 PubChem CID: 397887 Isomeric SMILES: COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CCCNCCO)OC.Cl