LY-411575 (C005B-313298)

Catalog No.: C005B-313298
Mfr. No.: SML0506-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $309.78

List Price: $344.20

Application LY-411575 has been used as a potent γ:-secretase inhibitor and Notch inhibitor. Biochem/physiol Actions LY-411575 is potent, cell permeable and selective γ:-secretase inhibitor that reduces Aβ:/42 after acute or

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Description
Specifications

Application

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.

Biochem/physiol Actions

LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

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UPC:: 51241814
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML0506-5MG
CAS:: 209984-57-6
Temperature Control Device:: Yes

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