InformationLY2584702 LY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.Targetsp70S6K 4 nMIn vitroIn HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.In vivoLY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. Specification: 0.98 Molecular Formula: C21H19F4N7 Molecular Weight: 445.42 PubChem CID: 25118925 Isomeric SMILES: CN1C=C(N=C1C2CCN(CC2)C3=NC=NC4=C3C=NN4)C5=CC(=C(C=C5)F)C(F)(F)F Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/L413817-SCI_8758341fa7cc0e1618eafbaa14b118c5.pdf
- UPC:
- 51111856
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- L413817-5mg
- CAS:
- 1082949-67-4
- Product Size:
- 5mg
- Hazard Statement Codes:
- H315:H319:H335
- Precautionary Statement Codes:
- P261:P280:P305+P351+P338
