LY272015 (C005B-309513)

Catalog No.: C005B-309513
Mfr. No.: SML3120-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $761.54

List Price: $846.15

Biochem/physiol Actions LY272015 is a high-affinity, 5-HT2B subtype-selective serotonin receptor antagonist (5-HT2B -log KB = 9.86, 5-HT2A/5-HT2C -log Ki = 7.

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Biochem/physiol Actions

LY272015 is a high-affinity, 5-HT2B subtype-selective serotonin receptor antagonist (5-HT2B -log KB = 9.86, 5-HT2A/5-HT2C -log Ki = 7.65/7.92) that exhibits antihypertensive efficacy in deoxycorticosterone acetate (DOCA)-salt-hypertensive rats in vivo (1, 3 mg/kg iv; 1x/wk for 4 wks). LY272015 inhibits mitral valve interstitial cell (MVIC) activation by 5HT in cultures (100 nM LY, 10 nM or 1 μM 5HT; canine MVIC) and ex vivo (100 μM LY, 10 μM 5HT; human MV), as well as mitigates angiotensin II infusion-provoked MV remodeling in mice in vivo (3 mg/kg via infusion by osmotic pumps 2x/wk).

UPC:: 51432304
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3120-25MG
CAS:: 172895-15-7

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