Lys-[Des-Arg9]Bradykinin TFA (C09-1143-031)

Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K i of 0.12 nM, 1.7 nM and 0.23 nM for human , mouse and rabbit B1 receptors , respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptorsIn VitroLys-[Des-Arg9]Bradykinin is formed by the proteolytic cleavage of bradykinin, exerts its effects through bradykinin B1 receptor (B1R). Lys-[Des-Arg9]Bradykinin (Lda-BK; 10 μM) enhances the secretion of IL-12p70 and inhibits the secretion of IL-12p40 by mature hMo-DCs. Pretreatment with Lys-[Des-Arg9]Bradykinin treatment reduces the migration of mature hMo-DCs toward medium alone, suggesting that Lys-[Des-Arg9]Bradykinin may inhibit the chemokinesis of mature hMo-DCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoLys-[Des-Arg9]Bradykinin (1 μg; intra-artenal injection; New Zealand White rabbits) treatment reduces peripheral vascular resistance in LPS-induced rabbits, but the effect is brief (T 1/2 is 118-195 s). MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:Bradykinin B1 Receptor (B1R). Specification: 10mM in DMSO Molecular Formula: C52H74F3N13O13 Molecular Weight: 1146.22