Polyethylene Glycol (PEGs & PEOs)

SPDP-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell.

SPDP-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell.

t-Boc-Aminooxy-PEG1-amine is a PEG derivative containing a Boc-protected aminooxy group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected aminooxy can be deprotected under mild acidic conditions and

t-Boc-Aminooxy-PEG1-amine is a PEG derivative containing a Boc-protected aminooxy group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected aminooxy can be deprotected under mild acidic conditions and

t-Boc-Aminooxy-PEG1-amine is a PEG derivative containing a Boc-protected aminooxy group and an amine group. The hydrophilic PEG spacer increases solubility in aqueous media. The protected aminooxy can be deprotected under mild acidic conditions and

t-Boc-Aminooxy-PEG12-acid is a PEG derivative containing a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a

t-Boc-Aminooxy-PEG12-acid is a PEG derivative containing a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a

t-Boc-Aminooxy-PEG12-acid is a PEG derivative containing a Boc-protected aminooxy group and a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a

t-Boc-Aminooxy-PEG12-NHS ester is a PEG derivative containing a t-Boc protected aminooxy group and an NHS ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The t-Boc can be removed under mild acidic conditions.

t-Boc-Aminooxy-PEG12-NHS ester is a PEG derivative containing a t-Boc protected aminooxy group and an NHS ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The t-Boc can be removed under mild acidic conditions.

t-Boc-Aminooxy-PEG12-NHS ester is a PEG derivative containing a t-Boc protected aminooxy group and an NHS ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The t-Boc can be removed under mild acidic conditions.

t-Boc-Aminooxy-PEG12-t-butyl ester is a PEG derivative containing a Boc-protected aminooxy group and a terminal carboxylic acid. The hydrophilic PEG spacer increases water solubility in aqueous media. The Boc-protected amine can be deprotected under