MC-GGFG-AM-(10Me-11F-Camptothecin)

Aladdin

Catalog No.: C09-1153-261
Manufacturer No.: M650761-1mg
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

Price: $709.08

List Price: $787.87

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Description
Specifications

MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3 . ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cellsIC50& Target:Topoisomerase I. Molecular Formula: C51H56FN9O14 Molecular Weight: 1038.04

UPC:: 12352208
Condition:: New
Availability:: 8-12 weeks
Weight:: 1.06 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: M650761-1mg
CAS:: 2873460-70-7
Product Size:: 1mg

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