MD2-TLR4-IN-1 (Compound 22m) is a potent inhibitor ofmyeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4). MD2-TLR4-IN-1 (compound 22m) inhibits lipopolysaccharide (LPS)-induced expression oftumor necrosis factor alpha (TNF-α)andinterleukin-6 (IL-6)in macrophages with IC50 of 0.89 μM and 0.53 μM, respectively.TargetsTLR4 ; IL-6 (Cell-free assay); TNF-α (Cell-free assay) ; 0.53 μM; 0.89 μM
Specification: Moligand™, ≥99%
Molecular Formula: C22H14Cl2N4O
Molecular Weight: 421.28
PubChem CID: 138454798
Isomeric SMILES: C1=CC(=C(C(=C1)Cl)C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC5=C(C=C4)NC=C5)Cl
- UPC:
- 51382903
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 0.07 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M412200-50mg
- CAS:
- 2249801-12-3
- Product Size:
- 50mg