MDBN (C09-0959-053)

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.product description：A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic ac. Specification: ≥98% Molecular Formula: C9H7NO4 Molecular Weight: 193.16 PubChem CID: 672296 Isomeric SMILES: C1OC2=C(O1)C=C(C=C2)/C=C/[N+](=O)[O-] Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/M275106-SCI_5d7ed73c653b1fea266e5f1d7191fc52.pdf