Macrophage-Derived/CCL22 Chemokine (MDC) , also known as stimulated T cell chemotactic protein (STCP¬1), is a CC chemokine initially isolated from clones of monocyte¬-derived macrophages. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL22 shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. CCL22 has mild activity for primary activated T lymphocytes and no chemoattractant activity for neutrophils, eosinophils or resting T lymphocytes. CCL22 may also be involved in certain aspects of activated T lymphocyte physiology, such astrafficking activated T lymphocytes to inflammatory sites. CCL22 interacts with the cell surface chemokine receptor CCR4. Recombinant Human MDC/CCL22 (67aa) produced in E. coli is a single non-glycosylated polypeptide chain containing 68 amino acids. A fully biologically active molecule, rhMDC(67aa) has a molecular mass of 8.0 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
- UPC:
- 41141516
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Z03336-25
