General description
MeDbz NovaSyn TGR resin is a second generation Dbz resin that overcomes the problem of branched peptide formation of the original and provides a robust approach to the synthesis of peptide thioesters by Fmoc SPPS. This product is used exactly in the same manner as standard Dbz resins except that special conditions are not required for loading of the first amino acid. Peptide chain extension is performed on the 4-anilino group, followed by formation of an imidazolidinone (MeNbz) with p-nitrophenyl chloroformate, and cleavage from the resin with TFA. The peptide-MeNbz is used directly in chemical ligation reactions to generate in situ the desired peptide thioester.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Legal Information
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Quality Level: 200. product line: NovaSyn®. TG, Novabiochem®. . form: solid. reaction suitability: reaction type: Fmoc solid-phase peptide synthesis. manufacturer/tradename: Novabiochem®. . application(s): peptide synthesis. functional group: amine. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51112600
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 8551570001
