Alteconazole

A macrodiolide antibiotic that displays anti-protozoal activity against both Plasmodium and Trypanosoma (IC₅₀s = 370 and 460 ng/ml, respectively) and cytotoxicity against MRC-5 cells (IC₅₀ = 870 ng/ml) enhances the anti-fungal

A macrodiolide antibiotic that displays anti-protozoal activity against both Plasmodium and Trypanosoma (IC₅₀s = 370 and 460 ng/ml, respectively) and cytotoxicity against MRC-5 cells (IC₅₀ = 870 ng/ml) enhances the anti-fungal

A selective inhibitor of B-RafV600E mutant melanoma cell proliferation (EC₅₀ = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC₅₀s = 900 nM) decreases phosphorylation of the B-Raf