Mepyramine tannate

An inhibitor of IDO (IC₅₀ = 7 &microM) that is effective in vivo prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice causes regression of tumors and prolongs survival when used in combination with

An inhibitor of IDO (IC₅₀ = 7 &microM) that is effective in vivo prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice causes regression of tumors and prolongs survival when used in combination with

General description JMJD3 (Jumonji domain-containing protein 3) is part of the family of novel JmjC domain-containing histone demethylation (JHDM) enzymes. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate.

Lysosome-associated membrane protein 1 (LAMP1), also termed Igp120, is a heavily glycosylated lysosomal membrane protein of about 120 kDa. It consists of a ~40 kDa core polypeptide with O-linked and 18 asparagine-linked oligosaccharide side chains.

Lysosome-associated membrane protein 1 (LAMP1), also termed Igp120, is a heavily glycosylated lysosomal membrane protein of about 120 kDa. It consists of a ~40 kDa core polypeptide with O-linked and 18 asparagine-linked oligosaccharide side chains.

A cell permeable diaminopyrimidine derived compound that acts as a highly potent and selective inhibitor of Aurora A (IC 50 = 48 nM). Acts by binding to the hinge region via a pyrazole moiety and stabilizes a DFG-in, inactive conformation of Aurora

Application Aurora-A Inhibitor I has been used to study its effect on cell viability of human megakaryoblastic cell line (SET-2) and human erythroleukemia cell line (HEL) by methylthiazoletetrazolium (MTT) assay. Biochem/physiol Actions

Application Aurora-A Inhibitor I has been used to study its effect on cell viability of human megakaryoblastic cell line (SET-2) and human erythroleukemia cell line (HEL) by methylthiazoletetrazolium (MTT) assay. Biochem/physiol Actions

A cell-permeable phenyl-indolyl maleimide compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of GSK-3&#946, JAK3, PKC&#945 and PKC&#952 (IC 50 = 3, 8, 13 and 68 nM, respectively) with excellent selectivity over

InformationStemRegenin 1 (SR1) StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay.In vitroStemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of 120 nM. Culture

SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with K i of 9.7 nM.In VitroSUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC 50 (half the maximal inhibitory

A cell-permeable synthetic peptide containing mouse TIRAP 151-138 , reverse sequence, fused to the Drosophila Antennapedia sequence. Serves as a control for TIRAP Inhibitor Peptide (Cat.