Atorvastatin

It is an atorvastatin intermediate, where atorvastatin is a selective, competitive HMG-CoA reductase (HMGCR) inhibitor which has been shown to lower LDL-cholesterol and triglyceride levels.

It is an atorvastatin intermediate, where atorvastatin is a selective, competitive HMG-CoA reductase (HMGCR) inhibitor which has been shown to lower LDL-cholesterol and triglyceride levels.

It is an atorvastatin intermediate, where atorvastatin is a selective, competitive HMG-CoA reductase (HMGCR) inhibitor which has been shown to lower LDL-cholesterol and triglyceride levels.

General description HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction

General description HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction

A cell-permeable biphenyldimethyl urea compound that inhibits adipose triglyceride lipase (ATGL) activity (IC 50 = 700 nM [Substrate] = [Triolein] = 165 &#181M) in a substrate-competitive (K i = 355 nM) and highly selective manner, exhibiting

Application Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL). Biochem/physiol Actions Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved

Application Atglistatin has been used as a selective inhibitor of adipose triglyceride lipase (ATGL). Biochem/physiol Actions Atglistatin is the first selective inhibitor of adipose triglyceride lipase (ATGL), the rate limiting enzyme involved

A potent, selective, and competitive inhibitor of ATGL (IC₅₀ = 0.7 &muM) does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases blocks lipolysis by ATGL in

A potent, selective, and competitive inhibitor of ATGL (IC₅₀ = 0.7 &muM) does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases blocks lipolysis by ATGL in

A potent, selective, and competitive inhibitor of ATGL (IC₅₀ = 0.7 &muM) does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases blocks lipolysis by ATGL in

A potent, selective, and competitive inhibitor of ATGL (IC₅₀ = 0.7 &muM) does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases blocks lipolysis by ATGL in