Antihypertensive bicyclo compounds

Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM: 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.

Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM: 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.

Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM: 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.

InformationTorkinib (PP242) Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays: targets both mTOR complexes with &gt:10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively. Torkinib (PP242)

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the

Application Employed in a double Heck-Mizoroki arylation leading to &#946,&#946-diarylated vinyl boronates which react with an additional aryl halide to form &#928-extended systems. This approach was used to prepare conjugated dendrimers.""

Application Employed in a double Heck-Mizoroki arylation leading to &#946,&#946-diarylated vinyl boronates which react with an additional aryl halide to form &#928-extended systems. This approach was used to prepare conjugated dendrimers.""

XL657 is an extremely potent and selective inhibitor of EGFR phosphorylation (IC50 = 0.3 nM). Inhibition of EGFR blocks signal transduction and thus impedes vascularization. Also inhibits other receptor tyrosine kinases such as Neu (ErbB2), Flk-1

XL657 is an extremely potent and selective inhibitor of EGFR phosphorylation (IC50 = 0.3 nM). Inhibition of EGFR blocks signal transduction and thus impedes vascularization. Also inhibits other receptor tyrosine kinases such as Neu (ErbB2), Flk-1