Antihypertensive secologanin tryptamine alkaloids

InformationOrantinib (TSU-68, SU6668) has greatest potency againstPDGFRautophosphorylation withKiof 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70,

Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase ( NEP ). Sampatrilat inhibits C-domain ACE ( K i =13.8 nM) 12.4-fold more potent than that for the N-domain ( K i =171.9 nM). Sampatrilat

Non-peptide Neurotensin Receptor 1 (NTS1) partial agonist (EC50 &lt:15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35.

application：tert-Butyl (S)-2-pyrrolidone-5-carboxylate can be used:As a starting material/synthon in the synthesis of angiotensin-converting enzyme inhibitors.In the synthesis of phenanthroindolizidine alkaloids named (+)-tylophorine and antofine.As

application：tert-Butyl (S)-2-pyrrolidone-5-carboxylate can be used:As a starting material/synthon in the synthesis of angiotensin-converting enzyme inhibitors.In the synthesis of phenanthroindolizidine alkaloids named (+)-tylophorine and antofine.As

application：tert-Butyl (S)-2-pyrrolidone-5-carboxylate can be used:As a starting material/synthon in the synthesis of angiotensin-converting enzyme inhibitors.In the synthesis of phenanthroindolizidine alkaloids named (+)-tylophorine and antofine.As

application：tert-Butyl (S)-2-pyrrolidone-5-carboxylate can be used:As a starting material/synthon in the synthesis of angiotensin-converting enzyme inhibitors.In the synthesis of phenanthroindolizidine alkaloids named (+)-tylophorine and antofine.As

application：tert-Butyl (S)-2-pyrrolidone-5-carboxylate can be used:As a starting material/synthon in the synthesis of angiotensin-converting enzyme inhibitors.In the synthesis of phenanthroindolizidine alkaloids named (+)-tylophorine and antofine.As

General description Natural product derived from plant source. Thevetin A is one of the cardiac glycosides found in yellow oleander.

InformationTimolol Maleate (MK-950) is a non-selective,beta-adrenergic receptorantagonist forβ1/β2withKiof 1.97 nM/2.0 nM.In vitroTimolol Maleate is a beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active.

TRYPSIN PTN 3.0 S