Mibefradil hydrochloride

A weak inhibitor of the menin-MLL fusion protein interaction (IC50 = 193 &muM), intended as a negative control compound for tests involving MI-2.

A weak inhibitor of the menin-MLL fusion protein interaction (IC50 = 193 &muM), intended as a negative control compound for tests involving MI-2.

A weak inhibitor of the menin-MLL fusion protein interaction (IC50 = 193 &muM), intended as a negative control compound for tests involving MI-2.

Biochem/physiol Actions MI192 is a potent and selective histone deacetylase 3 (HDAc 3) inhibitor that inhibits IL-6 production in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) but not healthy PBMCs.

A general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC₅₀ = 2.7 and 18.

A general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC₅₀ = 2.7 and 18.

A general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC₅₀ = 2.7 and 18.

A general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC₅₀ = 2.7 and 18.

Application Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc.

Application Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc.

Synonym(s): (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist Formula: C12H13NO4 Formula weight: 235.24 CAS Number: 478336-92-4 Harmonized Tariff Code:  2934.99

Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine, existing as a homotrimer in vivo . MIF was originally identified as a T cell derived factor responsible for the inhibition of macrophage migration.