Adenine

Biochem/physiol Actions NSC146109 is a potent activator of p53 that selectively inhibits growth of transformed cells without genotoxicity. NSC146109 activates p53 by inhibition of MDMX expression.

A reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells (EC₅₀ = 8.38 &microM) induces p53 mutant protein degradation via MDM2-mediated ubiquitination.

A reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells (EC₅₀ = 8.38 &microM) induces p53 mutant protein degradation via MDM2-mediated ubiquitination.

A reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells (EC₅₀ = 8.38 &microM) induces p53 mutant protein degradation via MDM2-mediated ubiquitination.

A reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells (EC₅₀ = 8.38 &microM) induces p53 mutant protein degradation via MDM2-mediated ubiquitination.

An ATP-competitive inhibitor of PAK4, preventing the phosphorylation of the PAK4 substrate GEF-H1 (IC₅₀ = 1.3 nM) and blocking anchorage-independent growth of a panel of tumor cell lines (IC₅₀ = 4.

An ATP-competitive inhibitor of PAK4, preventing the phosphorylation of the PAK4 substrate GEF-H1 (IC₅₀ = 1.3 nM) and blocking anchorage-independent growth of a panel of tumor cell lines (IC₅₀ = 4.

An ATP-competitive inhibitor of PAK4, preventing the phosphorylation of the PAK4 substrate GEF-H1 (IC₅₀ = 1.3 nM) and blocking anchorage-independent growth of a panel of tumor cell lines (IC₅₀ = 4.

InformationPF-9366 PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.TargetshMat2A (Cell-free assay): hMat2A (Cell-free assay) 170 nM(Kd): 420 nM.

InformationPF-9366 PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.TargetshMat2A (Cell-free assay): hMat2A (Cell-free assay) 170 nM(Kd): 420 nM.

InformationPF-9366 PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.TargetshMat2A (Cell-free assay): hMat2A (Cell-free assay) 170 nM(Kd): 420 nM.

InformationPF-9366 PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.TargetshMat2A (Cell-free assay): hMat2A (Cell-free assay) 170 nM(Kd): 420 nM.