Ambazone

AMG 511 is a potent and orally available pan inhibitor of class I PI3K s, with K i s of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα , β, δ and γ, respectively. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. AMG

AMG 511 is a potent and orally available pan inhibitor of class I PI3K s, with K i s of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα , β, δ and γ, respectively. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. AMG

A selective Aurora kinase inhibitor (IC₅₀s = 5, 4, and 1 nM for Aurora A, B, and C, respectively) inhibits the proliferation of 26 different tumor cell lines in vitro and is broadly active in multiple xenograft models.

AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.A highly selective Met inhibitor (IC50 = 9.3 nM).

AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.A highly selective Met inhibitor (IC50 = 9.3 nM).

AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.A highly selective Met inhibitor (IC50 = 9.3 nM).

AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.A highly selective Met inhibitor (IC50 = 9.3 nM).

AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.A highly selective Met inhibitor (IC50 = 9.3 nM).

AMG-208 is a potent small molecular c-Met inhibitor with an IC50 of 9.3 nM.A highly selective Met inhibitor (IC50 = 9.3 nM).

InformationAMG 900 is a potent and highly selective pan-Aurora kinasesinhibitor for Aurora A/B/C withIC50of 5 nM/4 nM /1 nM. It is &gt:10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.In vitroAMG 900 is a novel class

AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonistForm:SolidIC50&amp: Target:TRPM8.

AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonistForm:SolidIC50&amp: Target:TRPM8.