Ambazone

An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC 50 = 210 nM) and rescue PKR-dependent translation block (IC 50 = 100 nM).

A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos.

A cell-permeable salicylidene compound that is shown to directly target Ire&#9451 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER

InformationIsoxazole 9 (ISX-9) Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including TGF-β

Cell Line Origin Human Caucasian osteosarcoma Cell Line Description A revertant line of the KHOS/NP cell line. Established after overnight incubation at 40.

Lactobionic acid is an inhibitor of MMP.An inhibitor of matrix metalloproteinases.

M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical ( IC 50 =3.6 nM) and cellular ( IC 50 =3.4 nM) potency against the LMP7 subunit. M3258 shows strong

M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical ( IC 50 =3.6 nM) and cellular ( IC 50 =3.4 nM) potency against the LMP7 subunit. M3258 shows strong

M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 exerts high biochemical ( IC 50 =3.6 nM) and cellular ( IC 50 =3.4 nM) potency against the LMP7 subunit. M3258 shows strong

M4205 is a c-KIT inhibitor, with an IC 50 of 10 nM for c-KIT V654A. M4205 has high activity on c-KIT mutations in exon 11, 13, 17.IC50&amp: Target:c-KIT.

Application:WB: 1/1,000 - 1/2,000.

MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC 50 s of 4.45 and 3.18 μM, respectively.IC50&amp: Target:Mcl-1 4.45 μM (IC 50 ) Bcl-2 3.18 μM (IC 50 )Biological Activity:MCL-1/BCL-2-IN-2 (Compound