Ketotrexate

Application KT 5720 has been used as a chemical inhibitor of cell signaling pathway. It has also been used as a protein kinase A (PKA) inhibitor to study its effect on the nuclear import of CRTC1 in &#945-MSH-activated B16-F0 cells and on COX-2

DescriptionMethoxy poly(ethylene glycol) KAT 10K (mPEG KAT 10K) is a monofunctional, methyl ether PEG featuring a terminal potassium acyltrifluoroborate for facile, rapid functionalization. Potassium acyltrifluoroborates (KATs) are stable functional

DescriptionMethoxy poly(ethylene glycol) KAT 20K (mPEG KAT 20K) is a monofunctional, methyl ether PEG featuring a terminal potassium acyltrifluoroborate for facile, rapid functionalization. Potassium acyltrifluoroborates (KATs) are stable functional

DescriptionMethoxy poly(ethylene glycol) 2-pyridyl KAT 5K (mPEG KAT 5K) is a monofunctional, methyl ether PEG featuring a terminal potassium acyltrifluoroborate for facile, rapid functionalization. Potassium acyltrifluoroborates (KATs) are stable

General description MLK2 or mixed-lineage kinase 2 is a member of the serine/threonine kinase family, which activates MAPK8 JNK and MKK4/SEK1. MLK2 itself can be phoshorylated, and activated by JNK kinases.

A functionally selective inhibitor of Chk1 (Kd = 2 nM IC₅₀ = 3 nM) interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.

STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC 50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and

A selective, cell-permeable inhibitor of CK2 (IC₅₀ = 0.11 &microM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases induces cell death in Jurkat adult T cell leukemia cells (DC₅₀ = 7.