Piritrexim

General description The protooncogene PIM1 encodes a protein kinase upregulated in prostate cancer (Dhanasekaran et al., 2001 [PubMed 11518967]).

PARP/PI3K-IN-1 (compound 15) is a potent PARP/PI3K inhibitor with pIC 50 values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα , PI3Kβ , PI3Kδ , and PI3Kγ , respectively. PARP/PI3K-IN-1 is a highly effective anticancer compound

PARP/PI3K-IN-1 (compound 15) is a potent PARP/PI3K inhibitor with pIC 50 values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα , PI3Kβ , PI3Kδ , and PI3Kγ , respectively. PARP/PI3K-IN-1 is a highly effective anticancer compound

PARP/PI3K-IN-1 (compound 15) is a potent PARP/PI3K inhibitor with pIC 50 values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα , PI3Kβ , PI3Kδ , and PI3Kγ , respectively. PARP/PI3K-IN-1 is a highly effective anticancer compound

PARP/PI3K-IN-1 (compound 15) is a potent PARP/PI3K inhibitor with pIC 50 values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα , PI3Kβ , PI3Kδ , and PI3Kγ , respectively. PARP/PI3K-IN-1 is a highly effective anticancer compound

An inhibitor of p53-mediated apoptosis, preventing p53 binding at the mitochondrial surface without affecting p53 transactivational activities at 25 &muM, pifithrin-&mu reduces p53-mediated apoptosis triggered by nutlin also interacts

An inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis, preventing p53-mediated apoptosis by cytotoxic compounds in C8 cells at 10 &muM and in human umbilical vein endothelial cells at 30 &muM.

An inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis, preventing p53-mediated apoptosis by cytotoxic compounds in C8 cells at 10 &muM and in human umbilical vein endothelial cells at 30 &muM.

An inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis, preventing p53-mediated apoptosis by cytotoxic compounds in C8 cells at 10 &muM and in human umbilical vein endothelial cells at 30 &muM.

PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC 50 s of 7, 5530 and 70 nM for PIM1 , PIM2 , and PIM3 , respectively, inhibits the phosphorylation of BAD, a downstream target of PIM , with an EC 50 of 262 nM. PIM1-IN-1 shows no

PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC 50 s of 7, 5530 and 70 nM for PIM1 , PIM2 , and PIM3 , respectively, inhibits the phosphorylation of BAD, a downstream target of PIM , with an EC 50 of 262 nM. PIM1-IN-1 shows no

PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC 50 s of 7, 5530 and 70 nM for PIM1 , PIM2 , and PIM3 , respectively, inhibits the phosphorylation of BAD, a downstream target of PIM , with an EC 50 of 262 nM. PIM1-IN-1 shows no