Tamoxifen

4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, is a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer.

4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, is a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer.

4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, is a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer.

4-hydroxytamoxifen (OHT), an active metabolite of tamoxifen, is a selective estrogen receptor modulator, is in wide clinical use for the treatment and prevention of breast cancer.

Purity Limit: &ge 99% (HPLC) CAS No.: 68047-06-3 Molecular Formula: C26H29NO2 Molecular Weight: 387.51 MDL No.: MFCD00278780 Appearance: White to off-white powder Storage Temperature: Store at 0-8 °C

Purity Limit: &ge 99% (HPLC) CAS No.: 68047-06-3 Molecular Formula: C26H29NO2 Molecular Weight: 387.51 MDL No.: MFCD00278780 Appearance: White to off-white powder Storage Temperature: Store at 0-8 °C

Biochem/physiol Actions 4-Hydroxytamoxifen is an active metabolite of Tamoxifen. 4-Hydroxytamoxifen is formed by cytochrome P450 2D6 in human liver and is a potent and selective estrogen receptor antagonist.

A reactive metabolite of tamoxifen that is formed by the action of CYP3A4 in human liver can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety.

A reactive metabolite of tamoxifen that is formed by the action of CYP3A4 in human liver can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety.

Application Each vial contains ≥1X10⁶ viable cells.Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.

Deodorant Gel 1x Use .10oz pkt, 200/bg, 5bg/cs - CS/1000

Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen hydrochloride has the potential for breast cancer studyIn