Antiviral drugs

4-chloro-1-methyl-1H-pyrazolo[3,4-b]pyridine.

4-Chloro-2-(1H-pyrazol-3-yl)phenol undergoes Mannich reaction with N,N′-bis(methoxymethyl)diaza-18-crown-6 to afford NCH2N-linked bis(3-(5-chloro-2-hydroxy)pyrazol-1-ylmethyl)-substituted diazacrown ether (98% yield).

4-Chloro-2-(1H-pyrazol-3-yl)phenol undergoes Mannich reaction with N,N′-bis(methoxymethyl)diaza-18-crown-6 to afford NCH2N-linked bis(3-(5-chloro-2-hydroxy)pyrazol-1-ylmethyl)-substituted diazacrown ether (98% yield).

4-Chloro-5-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine.

4-Chlorophenyl isothiocyanate has been used in the synthesis of thiosemicarbazides. It was also used as building block for the synthesis of N-alkylated 2-arylaminobenzimidazoles.

Application 4-Cyanophenylacetic acid can be used as a nitrile precursor to synthesize 1,2,4,5-tetrazines by reacting with aliphatic nitriles and hydrazine in the presence of Lewis acid metal catalysts. It can also be used as a reactant to prepare:

4-Cyclopropyl-2-thiazolamine.

4-Ethyl-3-methyl-1-phenyl-1H-indeno[1,2-b]pyrazolo[4,3-e]pyridin-5-one.

4-Ethyl-3-methyl-1-phenyl-1H-indeno[1,2-b]pyrazolo[4,3-e]pyridin-5-one.

4-fluoro-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid.

Application：4-Fluoro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of the following:pyrazine and pyrimidine analogs of biarylaminesN-[trans-5-(3-cyanophenyl)bicyclo[3.1.0]hex-2-yl]-N′-[4-

Application：4-Fluoro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of the following:pyrazine and pyrimidine analogs of biarylaminesN-[trans-5-(3-cyanophenyl)bicyclo[3.1.0]hex-2-yl]-N′-[4-