Solifenacin

Mas antagonist that inhibits signaling by angiotensin (1-7), preventing vasodilation and insulin sensitization.

Mas antagonist that inhibits signaling by angiotensin (1-7), preventing vasodilation and insulin sensitization.

Mas antagonist that inhibits signaling by angiotensin (1-7), preventing vasodilation and insulin sensitization.

Biochem/physiol Actions Cryosim-3 is a water soluble, selective and potent agonist of TRPM8 (transient receptor potential melastatin 8) receptor. Cryosim-3 increases tear secretion in an animal model of dry eye disease.

Biochem/physiol Actions Cryosim-3 is a water soluble, selective and potent agonist of TRPM8 (transient receptor potential melastatin 8) receptor. Cryosim-3 increases tear secretion in an animal model of dry eye disease.

A cell imperbeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation inhibits the insulin-stimulated autophosphorylation of the 95-kDa &beta-subunit of the insulin receptor (IC₅₀ = 200 &microM in vitro).

A cell imperbeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation inhibits the insulin-stimulated autophosphorylation of the 95-kDa &beta-subunit of the insulin receptor (IC₅₀ = 200 &microM in vitro).

A competitive antagonist of muscarinic receptors that potently blocks signaling through M1, M2, and M3 (Kis = 25, 125, and 10 nM, respectively), resulting in muscle relaxation.

InformationSolifenacin (YM905) Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

InformationSolifenacin (YM905) Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

InformationSolifenacin (YM905) Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

InformationSolifenacin (YM905) Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.