Central nervous system drugs

ApplicationAutocamtide 2-related inhibitory peptide has been used:To inhibit calmodulin kinase II (CaMKII) action in virulent Theileria infected macrophagesTo study its influence on oxidative stress associated with neural cell death after

Ready-to-use for application in fluorescence microscopy procedures. With increasing age, the autofluorescent pigment lipofuscin accumulates in the cytoplasm of many cell types, including neurons.

A widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC 50 = 4.

An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC 50 = 2.8 and 1.

A fluorescently-tagged probe consisting of C-10 ceramide with an AV group attached to the end of the acyl chain.

A fluorescently-tagged probe consisting of C-10 ceramide with an AV group attached to the end of the acyl chain.

A fluorescently-tagged probe consisting of C-10 ceramide with an AV group attached to the end of the acyl chain.

A potent, orally bioavailable inhibitor of &gamma-secretase that more potently inhibits the cleavage of APP to A&beta40 than signaling through Notch (IC₅₀s = 0.30 and 58 nM, respectively) shows good pharmacokinetics in rats, dogs, and

Potent and selective antagonist for the CB1 receptor (Ki = 0.16-0.

Potent and selective antagonist for the CB1 receptor (Ki = 0.16-0.

Potent and selective antagonist for the CB1 receptor (Ki = 0.16-0.

General description This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate.