Combination antiparkinson agents

JNJ-40418677 is an orally active modulator of γ-secretase , can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease , with IC 50 s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can

High affinity prolyl oligopeptidase inhibitor: anti-angiogenic, neuroprotective and brain penetrant.

High affinity prolyl oligopeptidase inhibitor: anti-angiogenic, neuroprotective and brain penetrant.

High affinity prolyl oligopeptidase inhibitor: anti-angiogenic, neuroprotective and brain penetrant.

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stagesIn VitroLDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stagesIn VitroLDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stagesIn VitroLDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human

LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stagesIn VitroLDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human

Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. The structure of lectin is diversely studied in plants and animals.

A potent, selective inhibitor of LRRK2 that inhibits both wild-type and G2019S mutant LRRK2 (IC₅₀s = 13 and 6 nM, respectively) stimulates macroautophagy in H4 neuroglioma cells.

InformationLY-3381916 LY-3381916 is a potent, selective and brain penetrated IDO1 inhibitor.TargetsIDO1.

InformationLY-3381916 LY-3381916 is a potent, selective and brain penetrated IDO1 inhibitor.TargetsIDO1.