Diethylpropion hydrochloride

Neuroprotective and anticonvulsant agent.

GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors.

GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors.

GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors.

GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors.

A potent inhibitor of PKA and PKG that shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 &microM, respectively.

Antigen: fusion protein amino acids 660-779 (cytoplasmic C-terminus) of mouse HCN3 Host: mouse, clone S141-28 Isotype: IgG1 Cross Reactivity: (+) mouse and rat HCN3 Application(s): ICC, IHC, and WB Hyperpolarization-activated cation channels of the

Antigen: fusion protein amino acids 1,019-1,108 (cytoplasmic C-terminus) of rat HCN4 Host: mouse, clone S114-10 Isotype: IgG1 Cross Reactivity: (+) human, mouse, and rat HCN4 Application(s): ICC, IHC, and WB Hyperpolarization-activated cation

5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and

Biochem/physiol Actions Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v.

Biochem/physiol Actions Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v.

Hydroxybupropion-d8 is a major metabolite of Bupropion, an inhibitor of norepinephrine and dopamine reuptake.