Nicotine hydrochloride

A natural, nicotine-related alkaloid that binds the same receptor as nicotine, the nicotinic acetylcholine &alpha4&beta2 subtype (Ki = 38 nM) and increases nicotine-induced hyperactivity, sensitization, and intravenous self-administration.

Biochem/physiol Actions AR-R17779 is a nicotinic acetylcholine receptor alpha7 full agonist that targets &#945:7 nAChR with high affinity (Ki = 92 nM/rat &#945:7 against 5 nM &#945:-BTX vs.16 &#956:M/rat &#945:4&#946:2 against 3 nM (-)-nicotine)

Biochem/physiol Actions AR-R17779 is a nicotinic acetylcholine receptor alpha7 full agonist that targets &#945:7 nAChR with high affinity (Ki = 92 nM/rat &#945:7 against 5 nM &#945:-BTX vs.16 &#956:M/rat &#945:4&#946:2 against 3 nM (-)-nicotine)

Application bPiDl hydrate may be used to study nicotinic receptor-mediated signaling. Biochem/physiol Actions bPiDI is an &#945:6&#946:2-specific antagonist that inhibits nicotine-evoked and endogenous dopamine release from rat striatal slices

Lobeline hydrochloride is an alkaloid that acts on nicotinic cholinergic receptors but is less potent than nicotine. It is also a VMAT2 ligand and an antagonist of μ-opioid receptors.Solubility ≥37.5 mg/mL in EtOH with ultrasonic: ≥37.8 mg/mL in H2O

Lobeline hydrochloride is an alkaloid that acts on nicotinic cholinergic receptors but is less potent than nicotine. It is also a VMAT2 ligand and an antagonist of μ-opioid receptors.Solubility ≥37.5 mg/mL in EtOH with ultrasonic: ≥37.8 mg/mL in H2O

Lobeline hydrochloride is an alkaloid that acts on nicotinic cholinergic receptors but is less potent than nicotine. It is also a VMAT2 ligand and an antagonist of μ-opioid receptors.Solubility ≥37.5 mg/mL in EtOH with ultrasonic: ≥37.8 mg/mL in H2O

General description Monoamine Oxidase A contains binding sites for 8&#945:-S-cysteinyl-FAD. Monoamine oxidases metabolize biogenic amines in the central nervous system and the peripheral tissue.

NMR reference standard (2&nbspmg/mL in chloroform-d (99.8 atom % D), TMS 0.

A widely used, nonspecific CYP450 inhibitor that potentiates the effects of many different different drugs by inhibiting their metabolism (IC₅₀ values in the &muM range when tested using human liver microsomes) also acts as a

A widely used, nonspecific CYP450 inhibitor that potentiates the effects of many different different drugs by inhibiting their metabolism (IC₅₀ values in the &muM range when tested using human liver microsomes) also acts as a

A widely used, nonspecific CYP450 inhibitor that potentiates the effects of many different different drugs by inhibiting their metabolism (IC₅₀ values in the &muM range when tested using human liver microsomes) also acts as a