Phenicarbazide

JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC 50 =10 nM, K i =7.1 nM: rP2X7: IC 50 =15 nM, K i =2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult

JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC 50 =10 nM, K i =7.1 nM: rP2X7: IC 50 =15 nM, K i =2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult

General description This substance is supplied with certified chromatographic purity. The exact value can be found on the certificate.

General description This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate.

General description This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate.

General description This substance is supplied with certified chromatographic purity. The exact value can be found on the certificate.

Biochem/physiol Actions PF-05085727 is a potent inhibitor against cGMP-dependent phosphodiesterase PDE2 (PDE2A: IC50 = 2.3 nM) with &gt:500-fold selectivity over other PDEs.

Biochem/physiol Actions PF-05085727 is a potent inhibitor against cGMP-dependent phosphodiesterase PDE2 (PDE2A: IC50 = 2.3 nM) with &gt:500-fold selectivity over other PDEs.

PF-06372865 is an orally active, α2/α3/α5 subtype-selective GABA A positive allosteric modulator (PAM). PF-06372865 is a high affinity ligand at GABA A receptors containing α1/α2/α3/α5 subunits ( K i s of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2

InformationPF-06447475 PF-06447475 is a potent, selective, and brain penetrant LRRK2 kinase inhibitor with IC50 of 3 nM.TargetsLRRK2 (Cell-free assay): G2019S LRRK2 (Cell-free assay) 3nM: 11nMIn vitroIn the macrophage cell line Raw264.7, PF-06447475

InformationPF-06447475 PF-06447475 is a potent, selective, and brain penetrant LRRK2 kinase inhibitor with IC50 of 3 nM.TargetsLRRK2 (Cell-free assay): G2019S LRRK2 (Cell-free assay) 3nM: 11nMIn vitroIn the macrophage cell line Raw264.7, PF-06447475

InformationPF-06447475 PF-06447475 is a potent, selective, and brain penetrant LRRK2 kinase inhibitor with IC50 of 3 nM.TargetsLRRK2 (Cell-free assay): G2019S LRRK2 (Cell-free assay) 3nM: 11nMIn vitroIn the macrophage cell line Raw264.7, PF-06447475