Xylazine hydrochloride

XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum

Biochem/physiol Actions XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds

XBridge BEH Phenyl Method Validation Kit, 130Å, 3.5 µm, 3 mm X 150 mm, 3/pk

XBridge BEH Phenyl Method Validation Kit, 130Å, 3.5 µm, 4.6 mm X 100 mm, 3/pk

XBridge BEH Phenyl Method Validation Kit, 130Å, 3.5 µm, 4.6 mm X 150 mm, 3/pk

XBridge BEH Phenyl Method Validation Kit, 130Å, 2.5 µm, 2.1 mm X 100 mm, 3/pk

XBridge BEH Phenyl Method Validation Kit, 130Å, 2.5 µm, 3 mm X 150 mm, 3/pk

XBridge BEH Phenyl Method Validation Kit, 130Å, 2.5 µm, 4.6 mm X 50 mm, 3/pk

XBridge Peptide BEH C18 XP Column, 130Å, 2.5 µm, 2.1 mm X 150 mm, 3/pkg

XBridge Peptide BEH C18 XP Column, 130Å, 2.5 µm, 3 mm X 150 mm, 3/pkg

XBridge Peptide BEH C18 XP Column, 130Å, 2.5 µm, 3 mm X 150 mm, 1/pk

A selective inverse agonist of ERR&alpha (IC₅₀ = ~300-500 nM) blocks ERR&alpha/PGC-1&alpha-dependent signaling, suppressing the expression of MAO A and B induces proteasomal degradation of ERR&alpha and potentiates the degradation