Combination opioid-containing antitussives

General description Opioid peptides are endogenous neuromodulators that play a major role in nociception by interacting with several membrane receptors. Molecular cloning techniques have characterized the nucleotide sequence of several distinct

Opiates derived from the opium poppy, Papaver somniferum, have been used for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to

Specificity Mu Opioid receptor. Immunogen Synthetic peptide (Catalog number AG375) from the C-terminus of rat mu Opioid receptor corresponding to residues 384-398 of the rat mu opioid receptor.

General description The gene OPRM1 (opioid receptor &#956: 1) is mapped to human chromosome 6q24-q25. The gene spans a length of 200kb and contains 11 exons that yield 17 splice variants.

Biochem/physiol Actions ARM390 in a &#948:-selective opioid receptor agonist derivative of SNC80. ARM390 leads to very low levels of receptor internalization, and does not induce acute desensitization of analgesic response compared to SNC80.

Biochem/physiol Actions ARM390 in a &#948:-selective opioid receptor agonist derivative of SNC80. ARM390 leads to very low levels of receptor internalization, and does not induce acute desensitization of analgesic response compared to SNC80.

InformationAsimadoline (EMD 61753) is a potent κ opioid receptor agonist with IC50 of 5.6 nM and 1.2 nM for guinea pig and human recombinant κ opioid receptor, respectively.

InformationAsimadoline (EMD 61753) is a potent κ opioid receptor agonist with IC50 of 5.6 nM and 1.2 nM for guinea pig and human recombinant κ opioid receptor, respectively.

InformationAsimadoline (EMD 61753) is a potent κ opioid receptor agonist with IC50 of 5.6 nM and 1.2 nM for guinea pig and human recombinant κ opioid receptor, respectively.

InformationAsimadoline (EMD 61753) is a potent κ opioid receptor agonist with IC50 of 5.6 nM and 1.2 nM for guinea pig and human recombinant κ opioid receptor, respectively.

Cav 2.2 blocker 2 is a Cav2.2 calcium channel blocker extracted from patent WO2017046581A1, compound 1. Cav 2.2 blocker 2 can reverses hyperalgesia associated with an injury or inflammation in conjunction with the opioid.Form:SolidIC50&amp:

Cav 2.2 blocker 2 is a Cav2.2 calcium channel blocker extracted from patent WO2017046581A1, compound 1. Cav 2.2 blocker 2 can reverses hyperalgesia associated with an injury or inflammation in conjunction with the opioid.Form:SolidIC50&amp: