Narceine

InformationDS-1971a is a potent, selective, and orally active inhibitor of NaV1.7 with IC50 of 22.8 nM and 59.4 nM for hNaV1.7 and mNaV1.7, respectively. DS-1971a exerts analgesic effects.

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC 50 of 8 nM. Pain relief. Limited CNS penetrationIn VivoNav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC 50 of 8 nM. Pain relief. Limited CNS penetrationIn VivoNav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC 50 of 8 nM. Pain relief. Limited CNS penetrationIn VivoNav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profileIn VitroPF-06305591 (compound 9) has a highly attractive profile with respect

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profileIn VitroPF-06305591 (compound 9) has a highly attractive profile with respect

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profileIn VitroPF-06305591 (compound 9) has a highly attractive profile with respect

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profileIn VitroPF-06305591 (compound 9) has a highly attractive profile with respect

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profileIn VitroPF-06305591 (compound 9) has a highly attractive profile with respect