Drugs affecting the gastrointestinal system

One of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid, where the biological activity of (±)15-HETE is similar to that of its constituent enantiomers.

One of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid, where the biological activity of (±)15-HETE is similar to that of its constituent enantiomers.

Eicosapentaenoic acid (EPA) is an ω-3 fatty acid in marine organisms. 17,18-DiHETE is a major metabolite produced when EPA is incubated with various rat tissue homogenates or cynomolgus monkey seminal vesicles. The route of production of

Eicosapentaenoic acid (EPA) is an ω-3 fatty acid in marine organisms. 17,18-DiHETE is a major metabolite produced when EPA is incubated with various rat tissue homogenates or cynomolgus monkey seminal vesicles. The route of production of

(±)17-HDoHE is an autoxidation product of docosahexaenoic acid (DHA)|in vitro|. It has been found to be produced from incubations of DHA in rat brain, intestinal microsomes and liver. (±)17-HDoHE has been shown to inhibit U-46619-induced rabbit and

(±)17-HDoHE is an autoxidation product of docosahexaenoic acid (DHA)|in vitro|. It has been found to be produced from incubations of DHA in rat brain, intestinal microsomes and liver. (±)17-HDoHE has been shown to inhibit U-46619-induced rabbit and

(±)17-HETE.

(±)17-HETE.

Product DescriptionEpoxide hydrolases convert the EETs into vicinal diols, with concurrent loss of much of their biological activity. It is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F1α metabolites in

Product DescriptionEpoxide hydrolases convert the EETs into vicinal diols, with concurrent loss of much of their biological activity. It is a substrate for sheep seminal vesicle COX, producing 5,6-dihydroxy prostaglandin E1 and F1α metabolites in

Produced by non-enzymatic oxidation of EPA resulting in a racemic mixture of 5-HEPE. The biological activity is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in

Produced by non-enzymatic oxidation of EPA resulting in a racemic mixture of 5-HEPE. The biological activity is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in