Amylase/dehydrocholic acid/protease

A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in aggressive cancers from various tissues (IC50 = 150 nM when tested as a racemic mixture in SK0V-3 cells) activity of the

A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in addressive cancers from various tissues (IC₅₀ = 150 nM when tested as a racemic mixture in SK0V-3 cells) activity of

A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in addressive cancers from various tissues (IC₅₀ = 150 nM when tested as a racemic mixture in SK0V-3 cells) activity of

A single enantiomer of a potent and selective inactivator of KIAA1363, a MAGE hydrolase an enzyme that is upregulated in addressive cancers from various tissues (IC₅₀ = 150 nM when tested as a racemic mixture in SK0V-3 cells) activity of

Application (2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation . Incorporation of rigidity into the linker region of bifunctional

General description Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase. Application (6R)-BH 4 has been used as a buffer

General description Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase. Application (6R)-BH 4 has been used as a buffer

General description Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase. Application (6R)-BH 4 has been used as a buffer

4-(Trifluoromethyl)phenylacetic acid undergoes diolefination mediated by mono- N -protected amino acid ligands in the presence of ethyl acrylate, Pd(OAc) 2 , KHCO 3 and t -amyl alcohol .

Application ( S , R , S )-AHPC-Me-C 5 -COOH is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader

1 3-DIFURFURYLUREA

A competitive inhibitor of HIF prolyl 4-hydroxylase (IC₅₀ = 2.4-3.6 &microM).