Darifenacin or darifenacin hydrobromide

An inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53 binds to p53 with an apparent Kd value of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation, and

An inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53 binds to p53 with an apparent Kd value of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation, and

An inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53 binds to p53 with an apparent Kd value of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation, and

An inhibitor of p53-HDM-2 interaction that can reactivate the tumor suppressor function of wild-type p53 binds to p53 with an apparent Kd value of 1.5 nM and prevents interaction with HDM-2 resulting in p53 stabilization, accumulation, and

InformationRK-287107 RK-287107 is a novel, potent and selective tankyrase inhibitor with antitumor activity. RK-287107 inhibits tankyrase-1 and tankyrase-2 in vitro with IC50 of 14.3 nM and 10.6 nM.TargetsTankyrase-2 (Cell-free assay): Tankyrase-1

A cell-permeable diaryl amide derived from T1317 (a known LXR agonist and retinoic acid receptor (ROR) inverse agonist) that acts as a highly selective agonist of ROR&#945/&#947 and does not exhibit affinity for FXR, LXRa and LXRb. Shown to

A pan-HDAC inhibitor (IC50 = 77 nM in an in vitro HDAC1 activity assay) that prevents proliferation of ovarian (A2780), colon (COLO 205 and HCT116), and prostate cancer (PC-3) cell lines at IC50 values of 0.48, 0.

A pan-HDAC inhibitor (IC50 = 77 nM in an in vitro HDAC1 activity assay) that prevents proliferation of ovarian (A2780), colon (COLO 205 and HCT116), and prostate cancer (PC-3) cell lines at IC50 values of 0.48, 0.

A pan-HDAC inhibitor (IC50 = 77 nM in an in vitro HDAC1 activity assay) that prevents proliferation of ovarian (A2780), colon (COLO 205 and HCT116), and prostate cancer (PC-3) cell lines at IC50 values of 0.48, 0.

A pan-HDAC inhibitor (IC50 = 77 nM in an in vitro HDAC1 activity assay) that prevents proliferation of ovarian (A2780), colon (COLO 205 and HCT116), and prostate cancer (PC-3) cell lines at IC50 values of 0.48, 0.

InformationSirtinol is a specificSIRT1andSIRT2inhibitor withIC50of 131 μM and 38 μM in cell-free assays, respectively.In vitroSirtinol potently inhibits recombinant yeast Sir2p activity in vitro with IC50 of 68 μM. Unlike TSA, Sirtinol has shown no

A cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 &muM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 &muM, respectively does not alter HDAC1