Glycerin/kaolin/sodium fluoride

The initial compound identified in a screen for PAD4 inhibitors (IC₅₀ = 3.2 &microM in functional assay) that was optimized to produce the more potent PAD4 inhibitors, GSK484 and GSK199.

The initial compound identified in a screen for PAD4 inhibitors (IC₅₀ = 3.2 &microM in functional assay) that was optimized to produce the more potent PAD4 inhibitors, GSK484 and GSK199.

The initial compound identified in a screen for PAD4 inhibitors (IC₅₀ = 3.2 &microM in functional assay) that was optimized to produce the more potent PAD4 inhibitors, GSK484 and GSK199.

Biochem/physiol Actions GSK180736A is a potent and selective dual inhibitor of a ROCK1 (Rho-associated, coiled-coil-containing protein kinase) and GRK2 (G protein-coupled receptor kinase 2). GSK180736A binds to the GRK2 active site.

Biochem/physiol Actions GSK180736A is a potent and selective dual inhibitor of a ROCK1 (Rho-associated, coiled-coil-containing protein kinase) and GRK2 (G protein-coupled receptor kinase 2). GSK180736A binds to the GRK2 active site.

A reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of NETs in both mouse and human neutrophils.

GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and &gt:8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity.

GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and &gt:8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity.

GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and &gt:8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity.

GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and &gt:8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity.

A selective, reversible inhibitor of FAS (pIC₅₀ = 7.8).

A selective, reversible inhibitor of FAS (pIC₅₀ = 7.8).