Metopimazine

A labeled Mesalazine metabolite.

An active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM IC₅₀ = 9 nM) that exhibits &gt50-fold selectivity for c-Met over a panel of tyrosine and serine-threonine kinases inhibits c-Met phosphorylation, as well as

An active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM IC₅₀ = 9 nM) that exhibits &gt50-fold selectivity for c-Met over a panel of tyrosine and serine-threonine kinases inhibits c-Met phosphorylation, as well as

An active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM IC₅₀ = 9 nM) that exhibits &gt50-fold selectivity for c-Met over a panel of tyrosine and serine-threonine kinases inhibits c-Met phosphorylation, as well as

An active-site inhibitor of the catalytic activity of c-Met kinase (Ki = 4 nM IC₅₀ = 9 nM) that exhibits &gt50-fold selectivity for c-Met over a panel of tyrosine and serine-threonine kinases inhibits c-Met phosphorylation, as well as

InformationPinometostat (EPZ5676) Pinometostat (EPZ5676) is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with K i of 80 pM in a cell-free assay, demonstrating &gt:37,000-fold selectivity against all other

A potent agonist of the serotonin 4 receptor (5-HT4, Ki = 3.9-31 nM also acts as an antagonist for the 5-HT2A, 5-HT2B, and 5-HT2C receptors (Ki = 32, 3.9, and 100 nM, respectively) stimulates colonic motility and transit in vivo.

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC 50 of 280 nM. UZH1b (IC 50 =28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC 50 of 280 nM. UZH1b (IC 50 =28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC 50 of 280 nM. UZH1b (IC 50 =28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC 50 of 280 nM. UZH1b (IC 50 =28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC 50 of 280 nM. UZH1b (IC 50 =28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has