Pancreatin

BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as

BRD7552 is a small molecule that induces expression of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD7552 dose-dependently increases PDX1 and insulin gene expression, as well as

Cell Line Origin Human primary pancreatic adenocarcinoma Cell Line Description Derived from a 61 year old female with a primary adenocarcinoma of the pancreas. BxPC-3 cells produce mucin and the tumour produced in a nude mouse is moderately well to

DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor ( IC 50 =3.6 nM). DX3-213B impairs ATP generation (IC 50 =11 nM), and blocks MIA PaCa-2 cell growth (GI 50 =11 nM). DX3-213B is used for the research

DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor ( IC 50 =3.6 nM). DX3-213B impairs ATP generation (IC 50 =11 nM), and blocks MIA PaCa-2 cell growth (GI 50 =11 nM). DX3-213B is used for the research

DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor ( IC 50 =3.6 nM). DX3-213B impairs ATP generation (IC 50 =11 nM), and blocks MIA PaCa-2 cell growth (GI 50 =11 nM). DX3-213B is used for the research

DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor ( IC 50 =3.6 nM). DX3-213B impairs ATP generation (IC 50 =11 nM), and blocks MIA PaCa-2 cell growth (GI 50 =11 nM). DX3-213B is used for the research

A inhibitor of Epac1 and Epac2 (IC₅₀s = 3.2 and 1.4 &microM, respectively) blocks Akt phosphorylation and insulin secretion in pancreatic &beta cells and inhibits the migration of AsPC-1 and PANC-1 pancreatic cancer cells in vitro.

A inhibitor of Epac1 and Epac2 (IC₅₀s = 3.2 and 1.4 &microM, respectively) blocks Akt phosphorylation and insulin secretion in pancreatic &beta cells and inhibits the migration of AsPC-1 and PANC-1 pancreatic cancer cells in vitro.

A inhibitor of Epac1 and Epac2 (IC₅₀s = 3.2 and 1.4 &microM, respectively) blocks Akt phosphorylation and insulin secretion in pancreatic &beta cells and inhibits the migration of AsPC-1 and PANC-1 pancreatic cancer cells in vitro.

A inhibitor of Epac1 and Epac2 (IC₅₀s = 3.2 and 1.4 &microM, respectively) blocks Akt phosphorylation and insulin secretion in pancreatic &beta cells and inhibits the migration of AsPC-1 and PANC-1 pancreatic cancer cells in vitro.

General description A cell-permeable, active site Zn 2+ -targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC 50 = 0.002, 0.