Potassium phosphate

DescriptionAdenylate Kinase (AK) (EC 2.7.4.3) is an abundant enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. The enzyme is found in the nucleus, cytosol, or

InformationAfuresertib (GSK2110183) is a potent, orally bioavailableAktinhibitor withKiof 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.TargetsAkt1 (Cell-free assay): Akt2 (Cell-free assay): Akt3 (Cell-free assay) 0.08

InformationAfuresertib (GSK2110183) is a potent, orally bioavailableAktinhibitor withKiof 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.TargetsAkt1 (Cell-free assay): Akt2 (Cell-free assay): Akt3 (Cell-free assay) 0.08

InformationAfuresertib (GSK2110183) is a potent, orally bioavailableAktinhibitor withKiof 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.TargetsAkt1 (Cell-free assay): Akt2 (Cell-free assay): Akt3 (Cell-free assay) 0.08

InformationAfuresertib (GSK2110183) is a potent, orally bioavailableAktinhibitor withKiof 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.TargetsAkt1 (Cell-free assay): Akt2 (Cell-free assay): Akt3 (Cell-free assay) 0.08

A reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (K d ~18 &#181M) and interfere with the Akt-phosphoinositide interaction, thus hindering

A cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC 50 = 58 nM, 210 nM, and 2.12 &#181M for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).

A cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC 50 = 58 nM, 210 nM, and 2.12 &#181M for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).

A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition &lt5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell

A highly cell-permeable and water soluble analog of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No.

Akt substrate is a synthetic substrate specific for Akt1. Sequence is related to the sequence surrounding the S phosphorylation site (amino acids 4–10) on glycogen synthase kinase-3β (GSK-3β).Akt substrateis a peptide substrate for Akt/PKBα.

4-Aminophenyl phosphate is an alkaline phosphatase substrate used to quantify enzyme activity in research models.