Calcitonin

A cell permeable, selective inhibitor of &mu-calpain (calpain-1) and m-calpain (calpain-2) crosses the blood-brain barrier to inhibit brain cysteine protease activity reported to have protective effects in numerous rodent models of neurotrauma

A cell permeable, selective inhibitor of &mu-calpain (calpain-1) and m-calpain (calpain-2) crosses the blood-brain barrier to inhibit brain cysteine protease activity reported to have protective effects in numerous rodent models of neurotrauma

A potent, cell-permeable, and irreversible inhibitor of calpain. Biochem/physiol Actions Cell permeable: yes Primary Target calpain Product does not compete with ATP.

Calpain Inhibitor VI is a cell permeable peptide aldehyde which functions as a reversible calpain inhibitor. Studies indicate that Calpain Inhibitor VI strongly inhibits cathepsin B and cathepsin L. In addition, Calpain Inhibitor VI reduces nuclear

Calpain Inhibitor VI is a cell permeable peptide aldehyde which functions as a reversible calpain inhibitor. Studies indicate that Calpain Inhibitor VI strongly inhibits cathepsin B and cathepsin L. In addition, Calpain Inhibitor VI reduces nuclear

Synonym(s): Z-L-Nva-CONH-CH2-2-Py Formula: C26H34N4O5 Formula weight: 482.60 Harmonized Tariff Code:  2924.19

Synonym(s): Z-L-Nva-CONH-CH2-2-Py Formula: C26H34N4O5 Formula weight: 482.60 Harmonized Tariff Code:  2924.19

A reversible and selective inhibitor of calpain I (&mu-calpain, Ki = 19 nM), with lower affinities for calpain II (m-calpain, Ki = 120 nM) and cathepsin B (Ki = 750 nM).

A reversible and selective inhibitor of calpain I (&mu-calpain, Ki = 19 nM), with lower affinities for calpain II (m-calpain, Ki = 120 nM) and cathepsin B (Ki = 750 nM).

Native calpain-1 from porcine erythrocytes. Ca 2+ -dependent heterodimeric cysteine proteinase with low Ca 2+ requirement (EC 50 = 2 &#181M).

An internally quenched fluorogenic substrate peptide derived from the calpain-1 cleavage site of &#945-spectrin. It is not recognized by trypsin or &#945-chymotrypsin and serves as a sensitive and specific substrate for calpain-1 (K m = 4.

An internally quenched peptide substrate that is optimized for calpain-1 amino acid recognition motifs at the primed as well as the non-primed sides. Shown to be kinetically superior, in terms of turnover rate, to Calpain Substrate III, Fluorogenic