Glimepiride/pioglitazone

AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC 50 of 38 nM for hLPA5. AS2717638 also significantly improves PGE 2 -, PGF 2α -, and AMPA-induced allodyniaForm:SolidIC50&amp: Target:IC50: 38 nM

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer

Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer

A selective, competitive, and highly bioavailable inhibitor of L-PGDS (Ki = 75 &microM) inhibits the production of PGD2 by L-PGDS-expressing cells purified from human CSF and recombinant mouse with an IC₅₀ value of 95 &microM.

A selective, competitive, and highly bioavailable inhibitor of L-PGDS (Ki = 75 &microM) inhibits the production of PGD2 by L-PGDS-expressing cells purified from human CSF and recombinant mouse with an IC₅₀ value of 95 &microM.

A selective, competitive, and highly bioavailable inhibitor of L-PGDS (Ki = 75 &microM) inhibits the production of PGD2 by L-PGDS-expressing cells purified from human CSF and recombinant mouse with an IC₅₀ value of 95 &microM.

A selective, competitive, and highly bioavailable inhibitor of L-PGDS (Ki = 75 &microM) inhibits the production of PGD2 by L-PGDS-expressing cells purified from human CSF and recombinant mouse with an IC₅₀ value of 95 &microM.

A GSK3&beta inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC₅₀ = 76 nM in vitro) stabilizes &beta-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment

A GSK3&beta inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC₅₀ = 76 nM in vitro) stabilizes &beta-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment

A GSK3&beta inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC₅₀ = 76 nM in vitro) stabilizes &beta-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment

Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC 50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-Vasotocin and

Biochem/physiol Actions Begacestat (GSI-953) is a selective &#947:-secretase inhibitor that selectively inhibits cleavage of APP over Notch. Other Notes This compound was developed by Pfizer for Neuroscience research .