Glimepiride/pioglitazone

InformationGNE-493 GNE-493 (compound 5) is a potent, selective and orally available dual inhibitor of pan- PI3-kinase and mTOR with IC50 of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.

InformationGNE-493 GNE-493 (compound 5) is a potent, selective and orally available dual inhibitor of pan- PI3-kinase and mTOR with IC50 of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.

InformationGNE-493 GNE-493 (compound 5) is a potent, selective and orally available dual inhibitor of pan- PI3-kinase and mTOR with IC50 of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.

InformationGNE-493 GNE-493 (compound 5) is a potent, selective and orally available dual inhibitor of pan- PI3-kinase and mTOR with IC50 of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.

InformationGNE-493 GNE-493 (compound 5) is a potent, selective and orally available dual inhibitor of pan- PI3-kinase and mTOR with IC50 of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.

InformationGNE-493 GNE-493 (compound 5) is a potent, selective and orally available dual inhibitor of pan- PI3-kinase and mTOR with IC50 of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively.

A selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S

A selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S

A selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S

Biochem/physiol Actions GPR39-C3 (TC-G-1008) is an orally available, potent and selective potent agonist of GPR39 that increases GLP-1 secretion in mice. GPR39-C3 exhibits showing an antidepressant-like effect in the forced swim test in mice.

Biochem/physiol Actions GPR39-C3 (TC-G-1008) is an orally available, potent and selective potent agonist of GPR39 that increases GLP-1 secretion in mice. GPR39-C3 exhibits showing an antidepressant-like effect in the forced swim test in mice.

GPR84 antagonist 1 is a high affinity and highly selective competitive antagonist of human GPR84 .Appearance:SolidBiological Activity:GPR84 antagonist 1 is a high affinity and highly selective competitive antagonist of human GPR84 .