Glimepiride/rosiglitazone

A potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM) produced in vivo via the metabolism of the prodrug acetorphan.

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that is synthesized principally in the stomach. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that is synthesized principally in the stomach. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.

V-0219 (Compound 9) is an orally active, positive allosteric modulator (PAM) of the Glukagon-like peptide-1 receptor (GLP-1R) . V-0219 can be used for obesity-associated diabetes researchIC50&amp: Target:GLP-1R.