Netoglitazone

Full-length human SSTR5 cDNA encoding sst5 Somatostatin (sst) is a multifunctional peptide with two biologically active forms, sst-14 and sst-28, which are synthesized in neurons throughout the brain as well as in peripheral tissues such as the

Prostaglandin D(2) (PGD(2)) is derived from arachidonic acid and binds with high affinity to the G-protein coupled receptors prostanoid DP(1) and DP(2). Interaction with DP(2) results in cell chemotaxis, eosinophil degranulation, eosinophil shape

An irreversible inhibitor of mutant forms of EGFR including T790M (Ki = 21.5 nM) with minimal activity at the wild-type EGFR (Ki = 303.

An irreversible inhibitor of mutant forms of EGFR including T790M (Ki = 21.5 nM) with minimal activity at the wild-type EGFR (Ki = 303.

CPL304110 is a potent, orally active and selective inhibitor of fibroblast growth factor receptors FGFR (1-3) , with IC 50 values of 0.75 nM, 0.5 nM, and 3.05 nM for FGFR (1-3), respectivelyIn VitroCPL304110 (0-0.6 μM) dose-dependently inhibits

CPL304110 is a potent, orally active and selective inhibitor of fibroblast growth factor receptors FGFR (1-3) , with IC 50 values of 0.75 nM, 0.5 nM, and 3.05 nM for FGFR (1-3), respectivelyIn VitroCPL304110 (0-0.6 μM) dose-dependently inhibits

CPL304110 is a potent, orally active and selective inhibitor of fibroblast growth factor receptors FGFR (1-3) , with IC 50 values of 0.75 nM, 0.5 nM, and 3.05 nM for FGFR (1-3), respectivelyIn VitroCPL304110 (0-0.6 μM) dose-dependently inhibits

CPL304110 is a potent, orally active and selective inhibitor of fibroblast growth factor receptors FGFR (1-3) , with IC 50 values of 0.75 nM, 0.5 nM, and 3.05 nM for FGFR (1-3), respectivelyIn VitroCPL304110 (0-0.6 μM) dose-dependently inhibits

A potent inhibitor of hedgehog-induced cellular activity (IC₅₀ = 100-200 nM) binds directly with the pathway activator Smo (Ki = 44 nM) blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of

InformationCZ415 CZ415, a potent ATP-competitive mTOR inhibitor with very good cell permeability.TargetsmTOR (Cell-free assay) 8.07(pIC50)In vitroCZ415 shows no genotoxic potential and has very good cell permeability. Treatment of CZ415 leads to

InformationCZ415 CZ415, a potent ATP-competitive mTOR inhibitor with very good cell permeability.TargetsmTOR (Cell-free assay) 8.07(pIC50)In vitroCZ415 shows no genotoxic potential and has very good cell permeability. Treatment of CZ415 leads to

InformationCZ415 CZ415, a potent ATP-competitive mTOR inhibitor with very good cell permeability.TargetsmTOR (Cell-free assay) 8.07(pIC50)In vitroCZ415 shows no genotoxic potential and has very good cell permeability. Treatment of CZ415 leads to