Pancreatic extract

A potent and selective pancreatic carcinogen in the Syrian golden hamster.

NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a K d of 16 nM and an IC 50 of 27 nM (in Hela cells). Anti-tumor activityIn VivoNMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse

NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a K d of 16 nM and an IC 50 of 27 nM (in Hela cells). Anti-tumor activityIn VivoNMS-P515 (80 mg/kg, orally daily for 12 days) exhibits potent antitumor activity in mouse

Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC 50 s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of

Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC 50 s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of

Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC 50 s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of

Amino Acid Sequence Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 General description Human peptide YY (PYY) is secreted by mucosal L cells in

Amino Acid Sequence Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 General description Human peptide YY (PYY) is secreted by mucosal L cells in

Amino Acid Sequence Tyr-Pro-Ala-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Ser-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2 Biochem/physiol Actions Gut hormone that inhibits both secretin and

Cell Line Origin Rat islet cell tumour Cell Line Description RIN-5F is a secondary clone of the rat islet tumour cell line RIN-m (Sigma Catalogue number. 95071701).

Cell Line Origin Rat islet cell tumour Cell Line Description Established from a transplantable pancreatic tumour of the islets of Langerhans. The tumour originated in an irradiated NEDH inhibited albino rat and was maintained by serial

General description Somatostatin is a peptide hormone widely distributed throughout the body and is an important regulator of endocrine and nervous system function. Somatostatin can also be found in gastrointestinal and bronchopulmonary endocrine