Pioglitazone

General description Monoclonal Anti-PSMA (mouse IgG1 isotype) is derived from the hybridoma 107-1A4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Prostate-specific membrane antigen (PSMA) is an integral, non-shed,

A competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 &microM) derepresses transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells at 250 &microM.

N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC 50 and pK d of 8.73 and 9.3, respectively.In VitroThe mean plasma half-lives for Pimavanserin and its

Dual PI 3-kinase and PDPK1 (PDK1) inhibitor.

Dual PI 3-kinase and PDPK1 (PDK1) inhibitor.

Research area: Cell signaling PI3 Kinase is a complex of N-terminal 6His-tagged, recombinant, full-length human p110&#945 containing the mutation E545K and untagged, recombinant, full-length human p85&#945. Biochem/physiol Actions p110&#945

Biochem/physiol Actions PaPE-1 is a Pathway Preferential Estrogen that activates the extranuclear signaling pathway without activating the nuclear signaling pathway. PaPE-1 bound 50,000-fold less well to ER&#945: and Er&#946: estrogen""

InformationPaxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor ofPI3KandmTORwith Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.TargetsPI3Kα (Cell-free assay): PI3Kδ (Cell-free assay): PI3Kγ

InformationPaxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor ofPI3KandmTORwith Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.TargetsPI3Kα (Cell-free assay): PI3Kδ (Cell-free assay): PI3Kγ

InformationPaxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor ofPI3KandmTORwith Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.TargetsPI3Kα (Cell-free assay): PI3Kδ (Cell-free assay): PI3Kγ

InformationPaxalisib (GDC-0084, RG7666) is a brain penetrant inhibitor ofPI3KandmTORwith Kiapp values of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.TargetsPI3Kα (Cell-free assay): PI3Kδ (Cell-free assay): PI3Kγ

General description Pigment epithelium-derived factor (PEDF) is a 47kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF is widely expressed in adult and fetal tissues, including brain, spinal cord, plasma, bone,