Pioglitazone

A selective inhibitor of PI3K&alpha with IC50 values of 2, 16, 660, and 220 nM for the &alpha, &beta, &gamma, and 2C&beta isoforms, respectively.

A selective inhibitor of PI3K&alpha with IC50 values of 2, 16, 660, and 220 nM for the &alpha, &beta, &gamma, and 2C&beta isoforms, respectively.

General description PI3K (p110alpha/p55gamma) or Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position which serve as second messengers in growth signaling pathways.

A cell permeable imidazopyridine-carboxylate derived compound that acts as a potent and selective inhibitor of phosphatidylinositol 3-kinase a (PI3Ka IC 50 = 800 pM). Blocks the proliferation of several cancer cells (IC 50 = 600 nM 1.

PI3K-IN-30 (compound 6d) is a potent PI3K inhibitor with IC 50 s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα , PI3Kβ , PI3Kγ and PI3Kδ , respectivelyForm:SolidIC50&amp: Target:PI3Kα 5.1 nM (IC 50 ) PI3Kβ 136 nM (IC 50 ) PI3Kγ 30.7 nM (IC 50 ) PI3Kδ 8.9

PI3K/mTOR Inhibitor-4 is an orally active pan-class I PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-4 has enzymatic inhibition activity for PI3Kα , PI3Kγ , PI3Kδ and mTOR with IC 50 values of 0.63 nM, 22 nM, 9.2 nM and 13.85 nM, respectively. PI3K/mTOR

Biochem/physiol Actions Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP

Biochem/physiol Actions Picropodophyllotoxin (PPP), an epimer of podophyllotoxin (PPT), has been reported to target insulin-like growth factor-I receptor (IGF-IR) and mediate anticancer functions. However, a study in 2007, has reported that PPP

Pifithrin α

Pifithrin α

An inhibitor of p53-mediated apoptosis, preventing p53 binding at the mitochondrial surface without affecting p53 transactivational activities at 25 &muM, pifithrin-&mu reduces p53-mediated apoptosis triggered by nutlin also interacts

An inhibitor of p53-mediated apoptosis, preventing p53 binding at the mitochondrial surface without affecting p53 transactivational activities at 25 &muM, pifithrin-&mu reduces p53-mediated apoptosis triggered by nutlin also interacts