Adalimumab

Avelumab with trade name Bavencio, is an FDA-approved drug to treat Merkel cell carcinoma, urothelial carcinoma, and renal cell carcinoma. Avelumab is a whole monoclonal antibody of isotype IgG1 that binds to the programmed death-ligand 1 (PD-L1)

Immunogen a 15 amino acid peptide from near the carboxy-terminus of human BANF1. Linkage The action of this antibody can be blocked using blocking peptide SBP4017 .

Three distinct signaling pathways lead to apoptosis. The death receptor and mitochondrion pathways are the two mains, which involve respectively caspase-8 and caspase-9.

Caspase-10 is a member of the peptidase C14A family and is involved in the activation cascade of caspases responsible for apoptosis execution. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and

General description The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and

Anti-dEGF Receptor, Extracellular Domain antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma C-273 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a recombinant

DIRAS family GTPase 3 (DIRAS3), also known as aplasia Ras homologue member I (ARHI), is an imprinted tumor suppressor gene. It is expressed in epithelial cells.

Immunogen a 16 amino acid peptide from near the amino-terminus of human DRAM. Application Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.

Physical form Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

General description The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.

General description LIM Kinase 1 (LIMK1) is a protein kinase that plays an important role in cellular functions like cell motility and growth cone actin dynamics. LIMK1 contains one PDZ domain and two LIM domains which mediate protein to protein

LPP (LIM domain containing preferred translocation partner in lipoma) is a member of group 3 of LIM (Lin11, Isl-1 &amp Mec-3) family of proteins. It is localized to human chromosome 3q28, has 10 exons, and spans around 400kb.